Factors affecting the release patterns of 5-fluorouracil from ethylene-vinyl acetate copolymer matrices.
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چکیده
منابع مشابه
Potential Use of Ethylene Vinyl Acetate Copolymer Excipient in Oral Controlled Release Applications: a Literature Review
Ethylene vinyl acetate copolymer (EVA) has a successful commercial history in the pharmaceutical industry as a controlled release excipient. The usage covers a wide spectrum of parenteral applications ranging from transdermal drug delivery, contraceptive insertions, subcutaneous implants and mucosal contact forms. The importance and prominence of EVA in parenteral applications has inspired rese...
متن کاملstudy of ethylene/vinyl acetate transformation to ethylene/vinyl alcohol copolymer by nmr and dsc
hydrolysis of ethylene-vinyl acetate copolymer in alkaline conditions using two systems of naoh/methanol and koh/isopropanol has been studied and the formation of ethylene-vinyl alcohol copolymer was systematically examined using nmr spectroscopy and dsc measurements. vinyl acetate weight percentage and the degree of hydrolysis were calculated from nmr spectroscopy and it is shown that hydrolys...
متن کاملControlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl acetate copolymer.
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) has been found to be an effective chemotherapeutic agent against brain tumors. However, because it has a very short half-life in plasma, the exposure of neoplastic cells to BCNU is very brief. The delivery of BCNU may be enhanced by using controlled release polymers. We measured the release of BCNU from ethylene-vinyl acetate copolymer (EVAc) into blo...
متن کاملEnhanced Controlled Transdermal Delivery of Mexazolam Using Ethylene-vinyl Acetate
Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
متن کاملEnhanced Controlled Transdermal Delivery of Mexazolam Using Ethylene-vinyl Acetate
Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1984
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.32.1633